E4 circulates between the mother and fetus during pregnancy3
E4 in NEXTSTELLIS is produced from a plant source4
E4 is the first new development in contraceptive estrogen in over 60 years5
E4 is an estrogen with a unique, selective, mechanism of action1-5
E4 has LOWER potency and binding affinity than that of E2 (itself less than EE) – so NEXTSTELLIS is dosed in mg not mcg2,9
Unlike other estrogens, E4 is selective and so has different actions in different tissues1,2,4,6-8,10
MINIMAL-TO-NO IMPACT:
Sex hormone binding globulin (SHBG)
Cholesterol*
Triglycerides*
Glucose*
Clotting factors*
*Compared with at baseline,
cycle 7, and cycle 14 in Phase 3 study
LOW IMPACT:
Inhibits estradiol-induced proliferation
HIGH IMPACT – good cycle control**
**Studied paired with a progestin
Maintains bone mineral density
Supports tissue maintenance
Supports tissue maintenance
Repairs and maintains tissue
Regulates vascular tone
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